ProteoNic and Novozymes Sign Agreement for UNic™ yield enhancer

Leiden, 14 December 2009 – ProteoNic, the protein expression experts, and Novozymes, the global leader in industrial enzymes and microorganisms, have signed an agreement in which Novozymes gains the right to use ProteoNic’s UNic™ expression toolbox and specifically UNic-FTee™ for one of its leading enzyme products. Novozymes has also taken an option to license UNic-FTee™ for commercial production.

ProteoNic and TNO Sign License Agreement

ProteoNic, the protein expression experts, announces
it has entered into a license agreement with the research organization TNO. Last year the parties formalized their collaboration on improving the expression yields of mammalian host systems using the ProteoNic proprietary UNic™ toolbox. In the past year the UNic-MTee™ (one of ProteoNic’s Translation Enhancement Element products) has proven successful in commercial production conditions using suspension CHO cells and serum free medium. TNO therefore, decided to obtain a commercial license for the production of modified pro-urokinase detection enzymes for use in its proprietary QuickZyme technology platform. The financial details of this deal were not disclosed.

ProteoNic and Genencor Sign Research Agreement

ProteoNic, the protein expression experts, and Genencor, a Danisco Division, have signed a research agreement. As part of the contract, the two biotech companies will use ProteoNic’s UNic™ Toolbox to investigate enzyme production for Genencor’s fungal expression platforms. ProteoNic will support Genencor in applying the unique protein yield enhancement products.

ProteoNic and Chr. Hansen Sign Service Agreement

ProteoNic, the protein expression experts, and Chr. Hansen, the Danish natural ingredient solution company, have signed a service agreement. The contract specifically includes construct design and cloning for applying its unique yield enhancement products. ProteoNic will also provide support in strain engineering to improve Chr. Hansen’s upstream production.

ProteoNic and Fraunhofer IME sign Research License and start collaboration on protein expression in

ProteoNic and Fraunhofer Institute of Molecular Biology and Applied Ecology (Fraunhofer IME) announce their collaboration regarding protein expression in plant systems. Fraunhofer IME has obtained a Research License to use ProteoNic’s UNic™ expression technology in a variety of its research projects. In addition, ProteoNic will support Fraunhofer IME by supplying its expertise and research services regarding translation optimization for the development of a plant expression system that produces antibodies at commercially relevant yields.